Table 2.

Association of CXCL12 SNP alleles with cervical cancer risk, Seattle-Puget Sound Region, 1986 – 2004

				Genetic Effects Model
		Frequency		Dominant	Recessive	Log Additive
SNP	Allele	Casesa	Controls	OR (95% CI)b	OR (95% CI)b	OR (95% CI)b
		N = 917	N=849
rs17885289	G	0.725	0.707
	A	0.275	0.293	0.92 (0.76–1.11)	0.88 (0.62–1.24)	0.93 (0.80–1.08)
rs2839685	C	0.865	0.865
	T	0.149	0.143	1.05 (0.85–1.30)	1.07 (0.47–2.40)	1.05 (0.86–1.27)
rs17880313	C	0.878	0.870
	T	0.128	0.125	1.05 (0.84–1.32)	0.95 (0.45–2.02)	1.04 (0.85–1.28)
rs7092453	A	0.806	0.813
	G	0.202	0.191	1.09 (0.89–1.33)	1.24 (0.76–2.00)	1.09 (0.92–1.29)
rs2236534	C	0.821	0.815
	A	0.195	0.195	1.01 (0.82–1.23)	0.94 (0.60–1.50)	1.00 (0.84–1.18)
rs266085	G	0.666	0.637
	A	0.350	0.377	0.89 (0.74–1.08)	0.74 (0.56–0.98)	0.88 (0.76–1.00)
rs1801157	G	0.821	0.797
	A	0.189	0.193	0.90 (0.74–1.10)	1.17 (0.67–2.03)	0.94 (0.79–1.11)
rs3740085	G	0.738	0.719
	C	0.247	0.242	1.02 (0.84–1.24)	0.94 (0.64–1.39)	1.01 (0.86–1.18)
rs266093	C	0.620	0.638
	G	0.388	0.362	1.11 (0.92–1.35)	1.23 (0.94–1.63)	1.12 (0.97–1.28)

Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio, CI, confidence interval.

Bold indicates significance level (P-value) below 0.05.

^aCases include squamous cell carcinoma (n=376), invasive adenocarcinoma (n=170), adenocarcinoma in situ (n=339), and adenosquamous carcinoma (n=32).

^bRisk estimates include all races, adjusted for age (categorically, as presented in Table 1) and race (white versus nonwhite).