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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Int J Immunogenet. 2009 Sep 24;36(6):367–375. doi: 10.1111/j.1744-313X.2009.00877.x

Table 3.

Risk of cervical cancer associated with common CXCL12 haplotypes, Seattle-Puget Sound Region, 1986 – 2004

Frequency Genetic Effects Model
Dominant Recessive Log Additive
Haplotypea Caseb Chromosomes Control
Chromosomes		 OR (95% CI)c OR (95% CI)c OR (95% CI)c
N = 1830 N=1696
000001100 0.188 0.200 0.88 (0.73–1.08) 1.06(0.62–1.82) 0.92 (0.77–1.09)
000010010 0.192 0.190 1.01 (0.83–1.23) 1.11 (0.69–1.79) 1.02 (0.86–1.20)
010000001 0.142 0.137 1.06 (0.86–1.31) 1.00 (0.43–2.32) 1.05 (0.86–1.28)
101100001 0.123 0.119 1.10 (0.87–1.38) 0.92 (0.43–2.00) 1.07 (0.87–1.32)
100001000 0.078 0.106 0.72 (0.56–0.93) 0.35 (0.12–0.97) 0.72 (0.57–0.90)
000001000 0.078 0.066 1.16 (0.88–1.54) 1.21 (0.27–5.45) 1.15 (0.88–1.51)
100100001 0.072 0.063 1.14 (0.86–1.51) 1.95 (0.46–8.33) 1.15 (0.88–1.50)
000000010 0.062 0.059 1.11 (0.82–1.50) 0.88 (0.26–2.90) 1.09 (0.82–1.44)
000000001 0.041 0.035 1.13 (0.78–1.62) - 1.14 (0.80–1.64)
000000000 0.008 0.010 1.02 (0.47–2.19) - 1.02 (0.47–2.18)

Abbreviations: SNP, single nucleotide polymorphism; OR, odds ratio, CI, confidence interval.

Odds ratios omitted where numbers were insufficient for calculation.

Bold indicates significance level (P-value) below 0.05.

a

Haplotypes defined by SNP alleles in chromosomal order from 5’ to 3’ across the CXCL12 gene region (rs17885289, rs2839685, rs17880313, rs7092453, rs2236534, rs266085, rs1801157, rs3740085, rs266093), where zero (0) indicates the common allele and one (1) indicates minor allele.

b

Cases include squamous cell carcinoma (n=376 subjects), invasive adenocarcinoma (n=169 subjects), adenocarcinoma in situ (n=339 subjects), and adenosquamous carcinoma (n=31 subjects).

c

Risk estimates include all races, adjusted for age (categorically, as presented in Table 1) and race (white versus nonwhite).