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. Author manuscript; available in PMC: 2010 Nov 15.
Published in final edited form as: Dev Biol. 2009 Aug 11;335(2):442–453. doi: 10.1016/j.ydbio.2009.08.004

Figure 1. Ftz and its partner Ftz-F1 are necessary for 5-HT2 stripe expression.

Figure 1

(A)5-HT2 expression is dependent upon ftz and ftz-f1. In situ hybridization of 5-HT2 mRNA: (i,ii,iii) OreR, at cellular blastoderm, gastrulation and early germ band extension; (iv) ftz9H34 mutant embryo; (v) ftz-f119 mutant embryo; and (vi) UAS-myc-ftz/NGT40 embryo. In either ftz or ftz-f1 mutants, 5HT-2 stripes were replaced by diffuse, low level expression. Ectopic ftz expression induced ectopic 5HT-2 expression. (B)5-HT2 and Ftz are coexpressed. Confocal images of embryos stained for 5-HT2 mRNA and Ftz protein. Stage 7 embryo: 5-HT2 RNA (red), Ftz protein (green), 5-HT2 RNA and Ftz protein merged. Note that overlapping expression in stripes does not produce a yellow color because Ftz protein is nuclear and 5-HT2 RNA is cytoplasmic.