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. Author manuscript; available in PMC: 2010 Dec 14.
Published in final edited form as: Neuroscience. 2009 Sep 12;164(3):1009–1019. doi: 10.1016/j.neuroscience.2009.09.013

Figure 6.

Figure 6

The temporal profile of GABA-induced IPSPs in NL neurons is not altered by modulation mediated by mGluRs (A) or GABAB receptors (B). GABAergic IPSPs were evoked by synaptic stimulations (duration of 500 ms) at different frequencies, under control (thin traces) and drug (thick traces) conditions (A: 100 μM tACPD, a non-specific mGluR agonist; B: 100 μM baclofen, a GABABR agonist). Due to a high intracellular Cl- concentration in NL neurons (Tang et al., 2009), activation of the GABAergic pathway gives rise to membrane depolarization up to about 15 mV. Discrete IPSPs were observed in response to a low frequency stimulation (10 Hz). Temporal summation of IPSPs occurred at higher frequencies. Activation of either mGluRs or GABAB receptors substantially reduced the amplitude of the IPSPs, but maintained a depolarizing plateau at high stimulation frequencies. Stimulation artifacts are blanked for clarity. The resting membrane potentials of the neurons were -65 (A) and -61 mV (B), respectively.