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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Cancer Res. 2009 Oct 20;69(21):8302–8309. doi: 10.1158/0008-5472.CAN-09-0798

Table 2.

Comparison of GEM prediction probabilities of chemosensitivity to actual tumor response and patient survival.

Cancer Type Study Name Agent or Combination GEM Score probability
Responders
(mean+/− 95% CI)
GEM Score probability
Non-Responders
(mean+/− 95% CI)
p-value
Responder vs. Non-Responder

Bladder BL-Jap Methotrexate 0.625 +/− 0.071 0.371 +/− 0.071 <0.001
Vinblastine 0.594 +/− 0.071 0.358 +/− 0.079 0.002
Adriamycin 0.552 +/− 0.078 0.402 +/− 0.090 0.049
Cisplatin 0.570 +/− 0.076 0.364 +/− 0.080 0.007
MVAC* 0.944 +/− 0.022 0.818 +/− 0.054 0.002

BL-Den Methotrexate 0.534 +/− 0.122 0.506 +/− 0.168 0.436
Vinblastine 0.602 +/− 0.192 0.490 +/− 0.166 0.331
Adriamycin 0.756 +/− 0.121 0.441 +/− 0.154 0.061
Cisplatin 0.783 +/− 0.075 0.442 +/− 0.148 0.012
MVAC* 0.996 +/− 0.002 0.871 +/− 0.104 0.033*

Ovarian OV-NC^ Carboplatin 0.715 +/− 0.074 0.563 +/− 0.141 0.034
Taxol 0.429 +/− 0.087 0.223 +/− 0.114 0.003
CT** 0.826 +/− 0.061 0.638 +/− 0.132 0.007

Breast BR-TX Taxol 0.568 +/− 0.130 0.345 +/− 0.072 0.002
5-FU 0.549 +/− 0.119 0.472 +/− 0.077 0.146
Adriamycin 0.326 +/− 0.135 0.164 +/− 0.061 0.019
Cyclophosphamide 0.340 +/− 0.138 0.218 +/− 0.071 0.064
FAC^ 0.721 +/− 0.116 0.576 +/− 0.072 0.021

BR-Ger Gemcitabine 0.219 +/− 0.046 0.154 +/− 0.033 0.014
Epirubicin 0.430 +/− 0.113 0.324 +/− 0.057 0.055
Docetaxel 0.804 +/− 0.076 0.726 +/− 0.042 0.044
GED^^ 0.919 +/− 0.034 0.859 +/− 0.023 0.003

Survivor vs. Deceased

Ovarian OV-GA Carboplatin 0.498 +/− 0.253 0.202 +/− 0.212 0.047
Taxol 0.397 +/− 0.227 0.114 +/− 0.136 0.025
CT** 0.721 +/− 0.213 0.310 +/− 0.224 0.008

Breast BR-Tai 5-FU 0.514 +/− 0.112 0.301 +/− 0.155 0.024
Adriamycin 0.211 +/− 0.107 0.036 +/− 0.042 0.002
Cyclophosphamide 0.263 +/− 0.118 0.114 +/− 0.124 0.052
FAC^ 0.611 +/− 0.120 0.392 +/− 0.177 0.033
*

Combination GEM for BL-Jap and BL-Den was made with the single-drug GEMs of Methotrexate, Vinblastin, Adriamycin and Cisplatin.

**

Combination GEM for OV-NC and OV-GA was made with the single-drug GEMs of Carboplatin and Taxol.

^

Combination GEM for BR-TX and BR-Tai was made with the single-drug GEMs for 5-FU, Adriamycin, and Cyclophosphamide.

^^

Combination GEM for BR-Ger was made with the single-drug GEMs of Gemcitabine, Epirubicin, Docetaxel.

P-value calculated by two- sample t-test.