Table 2.
Cancer Type | Study Name | Agent or Combination | GEM Score probability Responders (mean+/− 95% CI) |
GEM Score probability Non-Responders (mean+/− 95% CI) |
p-value† |
---|---|---|---|---|---|
Responder vs. | Non-Responder | ||||
Bladder | BL-Jap | Methotrexate | 0.625 +/− 0.071 | 0.371 +/− 0.071 | <0.001 |
Vinblastine | 0.594 +/− 0.071 | 0.358 +/− 0.079 | 0.002 | ||
Adriamycin | 0.552 +/− 0.078 | 0.402 +/− 0.090 | 0.049 | ||
Cisplatin | 0.570 +/− 0.076 | 0.364 +/− 0.080 | 0.007 | ||
MVAC* | 0.944 +/− 0.022 | 0.818 +/− 0.054 | 0.002 | ||
BL-Den | Methotrexate | 0.534 +/− 0.122 | 0.506 +/− 0.168 | 0.436 | |
Vinblastine | 0.602 +/− 0.192 | 0.490 +/− 0.166 | 0.331 | ||
Adriamycin | 0.756 +/− 0.121 | 0.441 +/− 0.154 | 0.061 | ||
Cisplatin | 0.783 +/− 0.075 | 0.442 +/− 0.148 | 0.012 | ||
MVAC* | 0.996 +/− 0.002 | 0.871 +/− 0.104 | 0.033* | ||
Ovarian | OV-NC^ | Carboplatin | 0.715 +/− 0.074 | 0.563 +/− 0.141 | 0.034 |
Taxol | 0.429 +/− 0.087 | 0.223 +/− 0.114 | 0.003 | ||
CT** | 0.826 +/− 0.061 | 0.638 +/− 0.132 | 0.007 | ||
Breast | BR-TX | Taxol | 0.568 +/− 0.130 | 0.345 +/− 0.072 | 0.002 |
5-FU | 0.549 +/− 0.119 | 0.472 +/− 0.077 | 0.146 | ||
Adriamycin | 0.326 +/− 0.135 | 0.164 +/− 0.061 | 0.019 | ||
Cyclophosphamide | 0.340 +/− 0.138 | 0.218 +/− 0.071 | 0.064 | ||
FAC^ | 0.721 +/− 0.116 | 0.576 +/− 0.072 | 0.021 | ||
BR-Ger | Gemcitabine | 0.219 +/− 0.046 | 0.154 +/− 0.033 | 0.014 | |
Epirubicin | 0.430 +/− 0.113 | 0.324 +/− 0.057 | 0.055 | ||
Docetaxel | 0.804 +/− 0.076 | 0.726 +/− 0.042 | 0.044 | ||
GED^^ | 0.919 +/− 0.034 | 0.859 +/− 0.023 | 0.003 | ||
Survivor vs. | Deceased | ||||
Ovarian | OV-GA | Carboplatin | 0.498 +/− 0.253 | 0.202 +/− 0.212 | 0.047 |
Taxol | 0.397 +/− 0.227 | 0.114 +/− 0.136 | 0.025 | ||
CT** | 0.721 +/− 0.213 | 0.310 +/− 0.224 | 0.008 | ||
Breast | BR-Tai | 5-FU | 0.514 +/− 0.112 | 0.301 +/− 0.155 | 0.024 |
Adriamycin | 0.211 +/− 0.107 | 0.036 +/− 0.042 | 0.002 | ||
Cyclophosphamide | 0.263 +/− 0.118 | 0.114 +/− 0.124 | 0.052 | ||
FAC^ | 0.611 +/− 0.120 | 0.392 +/− 0.177 | 0.033 |
Combination GEM for BL-Jap and BL-Den was made with the single-drug GEMs of Methotrexate, Vinblastin, Adriamycin and Cisplatin.
Combination GEM for OV-NC and OV-GA was made with the single-drug GEMs of Carboplatin and Taxol.
Combination GEM for BR-TX and BR-Tai was made with the single-drug GEMs for 5-FU, Adriamycin, and Cyclophosphamide.
Combination GEM for BR-Ger was made with the single-drug GEMs of Gemcitabine, Epirubicin, Docetaxel.
P-value calculated by two- sample t-test.