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Inhibition of cytokine release by VX-166 (n = 4 per assay).
| Cytokine/cell type | IC50 ± SD (nM) |
|---|---|
| IL-1β/LPS-treated human PBMC | 260 ± 120 |
| IL-18/SAC-treated human PBMC | 450 ± 170 |
IC50 = 50% inhibitory concentration; LPS = lipopolysaccharide; PBMC = peripheral blood mononuclear cells; SAC = Staphylococcus aureus cell suspension; SD = standard deviation.
