Table 1.
Comparison of MMP-9, MMP-10, and TIMP-1 serum levels between sepsis patients and controls (median and 25th to 75th percentiles are shown)
| Controls (n = 50) |
Sepsis patients (n = 192) |
P | |
|---|---|---|---|
| Gender female: number (%) | 13 (26.0) | 64 (33.3) | 0.11 |
| Age (years) | 57 (50-63) | 60 (49-70) | 0.39 |
| MMP-9 (ng/ml) | 498 (350-735) | 676 (308-1,164) | 0.07 |
| TIMP-1 (ng/ml) | 226 (213-241) | 618 (445-831) | <0.001 |
| MMP-10 (pg/ml) | 466 (288-614) | 1,880 (1,217-3,285) | <0.001 |
| MMP-9/TIMP-1 (ratio) | 2.19 (1.57-3.01) | 1.16 (0.49-2.24) | <0.001 |
| MMP-10/TIMP-1 (ratio) | 2.07 (1.17-2.84) | 3.09 (2.08-5.06) | <0.001 |
MMP = Matrix metalloproteinase; TIMP = tissue inhibitor of matrix metalloproteinase.