Table 3.
Comparison of MMP-9, MMP-10, TIMP-1, TNF-α, and IL-10 serum levels between surviving and nonsurviving sepsis patients (median and 25th to 75th percentiles are shown)
| Survivors (n = 125) |
Nonsurvivors (n = 67) |
P | |
|---|---|---|---|
| MMP-9: median ng/ml (percentile 25-75) | 784 (371-1222) | 554 (240-1044) | 0.037 |
| TIMP-1: median ng/ml (percentile 25-75) | 573 (422-724) | 797 (499-1,012) | <0.001 |
| MMP-10: median pg/ml (percentile 25-75) | 1,850 (1,187-2,956) | 2,284 (1,262-4,329) | 0.09 |
| MMP-9/TIMP-1 ratio: median (percentile 25-75) | 1.39 (0.63-2.42) | 0.82 (0.28-1.66) | 0.003 |
| MMP-10/TIMP-1 ratio: median (percentile 25-75) | 3.12 (2.14-5.06) | 2.97 (1.72-5.21) | 0.46 |
| TNF-α: median pg/ml (percentile 25-75) | 30 (19-51) | 34 (18-70) | 0.38 |
| IL-10: median pg/ml (percentile 25-75) | 10 (5-37) | 36 (9-103) | <0.001 |
| TNF-α/IL-10 ratio: median (percentile 25-75) | 2.49 (1.39-3.92) | 1.20 (0.47-2.38) | <0.001 |
IL = interleukin; MMP = matrix metalloproteinase; TIMP = tissue inhibitor of matrix metalloproteinase; TNF = tumor necrosis factor.