Table 4.
Correlation between MMP-9, MMP-10, and TIMP-1 serum levels with lactic acid, SOFA, platelets, and coagulation markers in sepsis patients
| Lactic acid (mmol/L) |
APACHE-II (points) |
SOFA (points) |
Platelet count (platelets/mm3) |
aPTT (seconds) |
INR (ratio) |
|
|---|---|---|---|---|---|---|
| MMP-9: ng/ml | Rho = -0.31 | Rho = -0.34 | Rho = -0.37 | Rho = 0.48 | Rho = -0.28 | Rho = -0.28 |
| P < 0.001 | P < 0.001 | P < 0.001 | P < 0.001 | P = 0.001 | P = 0.001 | |
| TIMP-1: ng/ml | Rho = 0.51 | Rho = 0.38 | Rho = 0.42 | Rho = -0.24 | Rho = 0.29 | Rho = 0.41 |
| P < 0.001 | P < 0.001 | P < 0.001 | P = 0.001 | P < 0.001 | P < 0.001 | |
| MMP-10: pg/ml | Rho = 0.29 | Rho = 0.33 | Rho = 0.36 | Rho = -0.24 | Rho = 0.13 | Rho = 0.22 |
| P < 0.001 | P < 0.001 | P < 0.001 | P < 0.001 | P = 0.13 | P = 0.008 | |
| MMP-9/TIMP-1 ratio | Rho = -0.45 | Rho = -0.42 | Rho = -0.48 | Rho = 0.49 | Rho = -0.38 | Rho = -0.4 |
| P < 0.001 | P < 0.001 | P < 0.001 | P < 0.001 | P < 0.001 | P < 0.001 | |
| MMP-10/TIMP-1 ratio | Rho = 0.01 | Rho = 0.11 | Rho = 0.04 | Rho = -0.08 | Rho = -0.09 | Rho = -0.03 |
| P = 0.95 | P = 0.13 | P = 0.77 | P = 0.30 | P = 0.29 | P = 0.72 |
aPTT = Activated partial thromboplastin time; INR = international normalized ratio; MMP = matrix metalloproteinase; rho = Spearman's rank correlation coefficient; SOFA = Sepsis-related Organ-Failure Assessment score; TIMP = tissue inhibitor of matrix metalloproteinase.