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. 2009 Sep 10;180(11):1143–1150. doi: 10.1164/rccm.200903-0393OC

TABLE 3.

STIMULUS–RESPONSE SLOPES FOR CARDIORESPIRATORY VARIABLES DURING HYPOXIA AND HYPERCAPNIA IN PATIENTS WITH OBSTRUCTIVE SLEEP APNEA AND CONTROL SUBJECTS

Patients with OSA (n = 20) CON Subjects (n = 20) P Value
Hypoxia response slopes
 Inline graphice, L/min/% SaO2 −0.51 ± 0.34 −0.47 ± 0.32 0.34
 MAP, mm Hg/% SaO2 −0.15 ± 0.53 −0.14 ± 0.28 0.48
 HR, bpm/% SaO2 −0.67 ± 0.30 −0.94 ± 0.44 0.01
 CVC, units/% SaO2 −0.65 ± 0.44 −1.02 ± 0.72 0.03
 FVC, units/% SaO2 −0.05 ± 0.09 −0.10 ± 0.09 0.04
Hypercapnia response slopes
 Inline graphice, L/min/mm Hg 2.21 ± 1.29 2.02 ± 1.48 0.34
 MAP, mm Hg/mm Hg 0.72 ± 1.00 0.59 ± 0.55 0.31
 HR, bpm/mm Hg 0.80 ± 0.68 0.80 ± 0.49 0.50
 CVC, units/mm Hg 2.01 ± 0.88 2.57 ± 0.89 0.03
 FVC, units/mm Hg
 −0.02 ± 0.18
 0.02 ± 0.12
 0.19

Definition of abbreviations: bpm = beats per minute; CVC = cerebrovascular conductance; FVC = forearm vascular conductance; HR = heart rate; MAP = mean arterial pressure; SaO2 = arterial oxygen saturation; Inline graphice = ventilation.

HR, CVC, and FVC responses to hypoxia and CVC responses to hypercapnia were blunted in patients with OSA versus CON subjects. Statistically significant values are in boldface type.