Table 3.
Diagnostic performance of CTCA in all patients
| Prevalence of disease (%) | N | TP | TN | FP | FN | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | LR+ | LR− | Diagnostic accuracy (%) | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All patients | 68 | 360 | 244 | 73 | 41 | 2 | 99 (97–100) | 64 (55–73) | 86 (81–89) | 97 (90–100) | 2.8 (2.2–3.5) | 0.13 (0.00–0.05) | 88 (85–91) |
| A: CS <10 | 24 | 62 | 15 | 42 | 5 | 0 | 100 (75–100) | 89 (76–96) | 75 (51–90) | 100 (90–100) | 9.4 (4.1–22) | 0.00 (0.00–n/an) | 92 (85–99) |
| B: CS 10 to <100 | 65 | 63 | 41 | 13 | 9 | 0 | 100 (89–100) | 59 (37–79) | 82 (68–91) | 100 (72–100 | 2.4 (1.5–4.0) | 0.00 (0.00–n/an) | 86 (77–94) |
| C: CS 100 to <400 | 75 | 118 | 86 | 15 | 15 | 2 | 98 (91–100) | 50 (32–68) | 85 (76–91) | 88 (62–98) | 2.0 (1.4–2.8) | 0.12 (0.02–0.38) | 86 (79–92) |
| D: CS ≥400 | 87 | 114 | 99 | 3 | 12 | 0 | 100 (95–100) | 20 (5–49) | 89 (82–94) | 100 (31–100) | 1.3 (1.0–1.6) | 0.00 (0.00–n/an) | 89 (84–95) |
| A vs. D | NS | p = 0.017 | NS | NS | p < 0.0001 | n/an | NS |
Diagnostic performance of CTCA in all patients combined, and in subgroups per Agatston CS (A: CS less than 10, B: CS between 10 and 100, C: CS between 100 and 400, and D: CS greater than 400). Specificity and positive likelihood ratio decreased with increasing CS (p-value for the comparison by Chi-squared test across groups A and D)
Abbreviations: N, number of patients; TP, true positive; at least one significant stenosis in a patient detected by CTCA and CCA regardless of location of stenosis; TN, true negative; no significant stenosis in a patient detected either by CTCA or CCA; FP, false positive; significant stenosis detected by CTCA and no significant stenosis detected by CCA; FN, false negative, no significant stenosis detected by CTCA and at least one significant stenosis detected by CCA; LR+, positive likelihood ratio; LR−, negative likelihood ratio; n/an, not analyzed (division by zero)