Table 4.

Diagnostic performance of CTCA in patients with (a) stable angina and (b) unstable angina

	Prevalence of disease (%)	N	TP	TN	FP	FN	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	LR+	LR−	Diagnostic accuracy (%)
(a) Stable angina	63	233	145	56	31	1	99 (96–100)	64 (53–74)	83 (76–88)	98 (89–100)	2.8 (2.1–3.7)	0.01 (0.00–0.08)	86 (82–91)
A: CS <10	16	43	7	32	4	0	100 (56–100)	89 (73–96)	64 (32–88)	100 (87–100)	9.0 (3.6–22.7)	0.00 (0.00–n/an)	91 (82–99)
B: CS 10 to <100	54	35	19	9	7	0	100 (79–100)	56 (31–79)	73 (52–88)	100 (63–100)	2.3 (1.3–4.0)	0.00 (0.00–n/an)	80 (67–93)
C: CS 100 to <400	70	76	52	13	10	1	98 (89–100)	57 (35–76)	84 (72–92)	93 (64–100)	2.3 (1.4–3.6)	0.03 (0.00–0.25)	86 (78–93)
D: CS ≥400	84	77	65	2	10	0	100 (93–100)	17 (3–49)	86 (76–93)	100 (20–100)	1.2 (0.9–1.5(	0.00 (0.00–n/an)	97 (80–95)
A vs. D							NS	p = 0.023	NS	NS	p < 0.0001	n/an	NS
(b) Unstable angina	79	127	99	17	10	1	99 (94–100)	63 (42–80)	91 (83–95)	94 (71–100)	2.7 (1.6–4.4)	0.02 (0.00–0.12)	91 (86–96)
A: CS <10	42	19	8	10	1	0	100 (60–100)	91 (57–100)	89 (51–100)	100 (66–100)	11.0 (1.7–71.3)	0.00 (0.00–n/an)	95 (85–100)
B: CS 10 to <100	79	28	22	4	2	0	100 (82–100)	67 (24–94)	92 (72–99)	100 (40–100)	3.0 (1.0–9.3)	0.00 (0.00–n/an)	93 (83–100)
C: CS 100 to <400	83	42	34	2	5	1	97 (93–100)	29 (5–70)	87 (72–95)	67 (13–98)	1.4 (0.9–2.2)	0.10 (0.01–1.39)	86 (75–96)
D: CS ≥400	92	37	34	1	2	0	100 (87–100)	33 (2–87)	94 (80–99)	100 (5–100)	1.5 (0.7–3.3)	0.00 (0.00–n/an)	95 (87–100)
A vs. D							NS	NS	NS	NS	p < 0.0001	n/an	NS

Diagnostic performance of CTCA in all patients with (a) stable angina and (b) unstable angina combined, and in subgroups per Agatston CS. Specificity and positive likelihood ratio decreased with increasing CS (p-value for the comparison by Chi-squared test across groups A and D)

Abbreviations as for Table 3