Table 6.

Definitions of severity assessment criteria for acute cholangitis

Mild (grade I) acute cholangitis
“Mild (grade I)” acute cholangitis is defined as acute cholangitis which responds to the initial medical treatmenta Moderate (grade II) acute cholangitis “Moderate (grade II)” acute cholangitis is defined as acute cholangitis that does not respond to the initial medical treatmenta
Moderate (grade II) acute cholangitis
“Moderate (grade II)” acute cholangitis is defined as acute cholangitis that does not respond to the initial medical treatmenta and is not accompanied by organ dysfunction
Severe (grade III) acute cholangitis
“Severe (grade III)” acute cholangitis is defined as acute cholangitis that is associated with the onset of dysfunction at least in any one of the following organs/systems:
1. Cardiovascular system	Hypotension requiring dopamine ≧5 µg/kg per min, or any dose of dobutamine
2. Nervous system	Disturbance of consciousness
3. Respiratory system	PaO2/FiO2 ratio < 300
4. Kidney	Serum creatinine > 2.0 mg/dl
5. Liver	PT-INR > 1.5
6. Hematological system	Platelet count < 100 000 /μl

Note: compromised patients, e.g., elderly (>75 years old) and patients with medical comorbidities, should be monitored closely

^a General supportive care and antibiotics