Table 2.

Neuropathological assessment for the accumulation of neurofibrillary tangles (immunostained for H-tau) and plaques (immunostained for amyloid-β: Aβ).

Cortical areas examined	Patients	P1	P2	P3	P4	P5	P6	P7	P8
	Diagnosis	AD IV/B	AD V/C	AD III/B	AD III (TAD*)	AD III/A and AGD	AD III (TAD*) and AGD	AD III/A and AGD	AD I (TAD*) and AGD
Entorhinal region	H-tau	+++	+++	+++	+++	+++	+++	+++	0
outer layers	Aβ	+	+	++	0	0	0	0	0
Entorhinal region	H-tau	+++	+++	+++	+++	++	+++	+++	0
inner layers	Aβ	+	+	++	0	0	0	0	0
Hippocampus	H-tau	+++	+++	++	++	++	++	0	0
	Aβ	+	+	0	0	0	0	0	0
Transentorhinal	H-tau	+++	+++	+++	+++	+++	+++	+++	++
region	Aβ	++	++	++	0	0	0	+	0
Occipito-temporal	H-tau	NA	+++	++	+++	+++	++	++	0
region (areas 36)	Aβ	NA	++	++	0	+	0	+	0
Temporal cortex	H-tau	NA	NA	0	0	0	0	0	0
(area 22)	Aβ	NA	NA	+	0	0	0	0	0
Frontal cortex	H-tau	NA	+++	0	0	0	0	0	0
(area 8)	Aβ	NA	+++	++	0	0	0	+	0
Occipital cortex	H-tau	NA	+++	0	0	0	+	0	0
(area 17)	Aβ	NA	+++	+	0	0	0	0	0
Occipital cortex	H-tau	NA	+++	0	0	0	0	0	0
(areas 18/19)	Aβ	NA	+++	+	0	+	0	0	0

The overall amount of neurofibrillary tangles and Aβ is graded and labeled zero (0) with no discernible change, (+) with small, (++) moderate, and (+++) large numbers of NFT and Aβ. AGD, argyrophilic grain disease; NA, material not available; TAD*, tangle-predominant variant of Alzheimer's disease; AD staging follows the nomenclature of Braak and Braak (1991).