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. 2009 Dec;331(3):1062–1070. doi: 10.1124/jpet.109.156216

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© 2009 by The American Society for Pharmacology and Experimental Therapeutics

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Fig. 6. — WIN-induced intracellular calcium release is required to block NMDA-mediated calcium influx in DRG neurons. A, WIN blocked NMDA-induced calcium rise. B, depletion of intracellular calcium store with TG inhibited the ability of WIN to block the NMDA-induced calcium rise. C, inhibition of intracellular calcium release by 2-APB-mediated inactivation of IP₃ receptors also inhibited the ability of WIN to block the NMDA-induced calcium rise. These representative examples of Ca²⁺ signals were recorded continuously during pharmacological challenges of DRG neurons in DPBS (n = 17 cells). The vertical and horizontal lines indicate the beginning and duration of the drug applications.