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. 2009 Dec;331(3):933–939. doi: 10.1124/jpet.109.160440

Fig. 1.

Fig. 1.

Scheme of the GlyR topology and the sequences of recombinant fragments. A, schematic topology of the human α1 GlyR subunit. B, alignment of intracellular fragments used for GST pull-down assays and molecular docking. Underlined are the sequences used for molecular modeling and docking. IL-WT, full α1 IL; NTIL-WT, N-terminal (17 amino acids) region of IL; NTIL-5A, mutant version with alanine substitutions; CFIL, central fragment (326–381) of IL; CTIL-WT, C-terminal region of IL; CTIL-2A, mutant version. The sequence of NTIL-WT served as template for the RQH peptide.