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Acute thermal antinociceptive effect of mixed NOP receptor/MOP receptor partial agonist SR16435 alone or coadministered with SB-612111 by use of the tail-flick assay at 10 min (A), 30 min (B), and 60 min (C) after injection. Data are mean %MPE (± S.E.M.). An asterisk (*) represents a significant difference from their respective vehicle controls, whereas a plus sign (+) represents a significant difference from SR16435 alone (P < 0.05).
