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. 2009 Nov 18;8:106. doi: 10.1186/1476-4598-8-106

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Copyright ©2009 Foster et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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A distinct CD5⁺CD19⁺SP phenotype is present in B-CLL patient peripheral blood. (A) PBMC collected from B-CLL patient P1300 were stained with Hoechst 33342 dye followed by antibody and propidium iodide labeling and subsequent analysis by flow cytometry. Cells were gated on either SP or NSP and examined for expression of CD5 and CD19 showing both populations are positive for CD5 and CD19. (B) CD5⁺CD19⁺SP frequency was analyzed longitudinally from PBMC samples collected prior to CD40L/IL-2 autologous B-CLL vaccination (left panel), during immunization (middle panel) and after immunization (right panel), demonstrating the elimination of B-CLL SP cells during treatment.