Table 2.

Drugs for which currently recommended anti-malarial regimens maybe inadequate in important patient groups.

Drug	Dose	Patient group	Comment
Dihydroartemisinin-piperaquine	2.5/20 mg/kg/day for 3 days	All	The current adult DHA dose of 120 mg may be too low. The piperaquine dose may be too low in children
Sulphadoxine -pyrimethamine	1.25/25 mg/kg	Children, pregnant women	Higher doses have not been evaluated
Atovaquone-proguanil	8/20 mg/kg for 3 days	Pregnant women	Higher doses have not been evaluated
Artemether-lumefantrine	1.5/9 mg/kg for 3 days with fat	Pregnant women Hyperparasitaemic patients	Lumefantrine absorption is dose limited. Longer courses have not been evaluated in pregnancy
Artesunate	Oral 2 mg/kg/day 7 days 2.4 mg/kg i.v.	Pregnant women	Higher doses have not been evaluated in pregnancy
Artemether	Oral 2 mg/kg/day 7 days 3.2 mg/kg i.m.	Pregnant women	Higher doses have not been evaluated in pregnancy

The efficacy of three day artemisinin-combination regimens in hyperparasitaemia is uncertain. Longer regimens may be necessary