Table 1.
Characteristics of study population according to HIV-1 status
| Characteristic | No HIV-1 infection (n = 224) |
HIV-1 infection (n = 115) |
P Value |
|---|---|---|---|
| Mean weight, kg (SD) | 56.98 | 56.89 | 0.95 |
| Number of women, N (%) | 98 (43.8) | 72 (62.6) | 0.001 |
| Mean age, years (SD) | 24.7 (9.1) | 29.5 (7.6) | <0.001 |
| Mean white blood cell count, *109/L (SD)† | 5.3 (1.9) | 5.1 (1.7) | 0.26 |
| Mean hemoglobin, g/L (SD) | 140 (20) | 124 (25) | <0.001 |
| Mean Log Viral load HIV-1 RNA copies/μL (SD) | 4.87 (0.64) | ||
| Mean (geometric) parasite density/μL (range)† | 9,715 (378-153,120) | 9,566 (390-158,894) | 0.92 |
| Mean (geometric) CD4 count baseline/μL (95%CI)‡ | 458 (427-492) | 259 (242-277) | <0.001 |
| Mean (geometric) CD4 count day45/μL (95%CI) § | 839 (769-915) | 379 (317-454) | <0.001 |
| Low responders to Combined merozoite antigens, N(%) | 42 (18.8) | 35 (30.4) | 0.02 |
| Low responders to Combined Variant Surface Antigens¶, N (%) | 68 (30.4) | 33 (28.7) | 0.75 |
*P value based on Students' t- test, Chi square or Wilcoxon Rank -Sum as required
† Data on WBC were missing in 1 patient in the non-HIV-1 infected group and in 2 in the HIV-1 infected group
‡ Data on baseline CD4 count were missing in 6 patients in the non-HIV-1 infected group and in 4 in the HIV-1 infected group
§Data on CD4 count on day 45 used only from patients without parasitaemia; non-HIV-1 infected group n = 108, HIV-1 infected group n = 66
//Low responders are <geometric mean for Merozoïte antigens AMA -1, MSP2 3D7 and MSP2 FC27 and Variant Surface Antigens from parasite lines E8B, A4, and HCD6.
¶After adjustment for CD4 count and age, low responders remained associated with HIV-1 infection (OR:2.40, P = 0.01), parasite load (OR: 1.62, P = 0.06) and absence of anemia (OR:0.55, P = 0.07).