Table 1.
Challenge of CD-1 mice with Sc237 Syrian hamster prions (38)
| Animal no. | Inoculum | Clinical signs of scrapie | Observation period, days* | Western blot, R073† | Western blot, 3F4‡ |
|---|---|---|---|---|---|
| 7007 | Sc237 | No | 408 | − | − |
| 7009 | Sc237 | No | 463 | − | − |
| 5531 | Sc237 | No | 483 | − | − |
| 5554 | Sc237 | No | 492 | − | − |
| 6967 | Sc237 | No | 530 | − | − |
| 5553 | Sc237 | No | 554 | − | − |
| 6969 | Sc237 | No | 641 | − | − |
| 5532 | Sc237 | No | 655 | − | − |
| 5528 | Sc237 | No | 659 | + | − |
| 7008 | Sc237 | No | 694 | + | − |
| 5538 | Sc237 | No | 703 | + | − |
| 5537 | Sc237 | No | 706 | + | − |
| 5539 | Sc237 | No | 706 | + | − |
| 6968 | Sc237 | No | 726 | + | − |
| 5540 | Sc237 | No | 730 | + | − |
| 7010 | Sc237 | No | 745 | + | − |
| 5530 | Sc237 | No | 769 | + | − |
| 5526 | Sc237 | No | 828 | + | − |
| 6954 | PBS | No | 436 | − | − |
| 6956 | PBS | No | 521 | − | − |
| 6953 | PBS | No | 586 | − | − |
| 6952 | PBS | No | 630 | − | − |
| 5533 | PBS | No | 683 | − | − |
| 5536 | PBS | No | 707 | − | − |
| 5535 | PBS | No | 780 | − | − |
| 5525 | PBS | No | 849 | − | − |
*
Mice either died from natural causes at advanced age or were culled because of intercurrent illness.
†
Detects both mouse and hamster PrP.
‡
Detects hamster PrP only.