Table 1.

Functional categories overrepresented with proteins whose absence renders cells more sensitive to NiSO₄.

MIPS Functional Category	p-value	In Category from Cluster	# Nickel Toxicity Modulating	Total in Category
homeostasis of proteins [34.01.01.03]	0.000556	VMA2 CUP5 RAV1 VMA6 STV1 VPH1	6	47
cation transport (H+, Na+, K+, Ca2+, NH4+, etc.) [20.01.01.01]	0.0007315	VMA2 CUP5 TOK1 MNR2 VMA6 STV1 VPH1	7	68
siderophone-iron transport [20.01.01.01.01.01]	0.002052	FTH1 AFT1 FET3	3	12
homeostasis of metal ions (Na, K, Ca etc.) [34.01.01.01]	0.006003	FTH1 CUP5 AFT1 TOK1 MNR2 MAC1 FET3	7	98
transport ATPases [20.03.22]	0.00621	VMA2 CUP5 VMA6 STV1 VPH1	5	53
metabolism of secondary products derived from L-lysine, L-arginine and L-histidine [01.20.31]	0.006963	JJJ3DPH2	2	6
endocytosis [20.09.18.09.01]	0.009743	FTH1 RVS161 CUP5 YPK1 WHI2	5	59