Table 2.

Integrin cross-talk with other receptor systems in endosomes (VEGFR vascular endothelial growth factor receptor, EGFR epidermal growth factor receptor, JAM-A junctional adhesion molecule-A)

Integrin	Other receptors	Physiological role	Reference
αvβ3	Integrin α5β1	Integrin αvβ3 inhibits recycling of α5β1; reduced invasion	White et al. 2007
αvβ3	EGFR	Integrin αvβ3 inhibits recycling of EGFR; reduced invasion	Caswell et al. 2008
α5β1	Neuroplilin-1	Neuropilin-1 induces α5β1 endocytosis	Valdembri et al. 2009
β1	T-cadherin	T-cadherin inhibits β1-integrin endocytosis	Mukoyama et al. 2007
β1	JAM-A	JAM-A internalization depends on β1-integrin endocytosis; neutrophil chemotaxis	Cera et al. 2009
αVβ3	VEGFR1	VEGFR1 stimulates recycling of αvβ3; fibronectin assembly	Jones et al. 2009
αVβ3, αVβ5	VEGFR2	Integrin inhibition results in increased VEGFR2 recycling and angiogenesis	Reynolds et al. 2009