Table 3.
Top gene networks identified to be perturbed during androgenindependent progression by Ingenuity pathway analysis
| Gene network(s) |
Score | Focus genes | Signaling Pathway(s) |
Biological function(s) | Status |
|---|---|---|---|---|---|
| 1 | 36 | 35 | TP53 | Negative regulation of growth | repressed |
| 2 | 36 | 35 | HGF | Growth signaling | activated |
| 3,4 | 36,36 | 35,35 | AP-1 (Jun/Fos) | Oncogenesis | repressed |
| 5 | 36 | 35 | VEGF | Angiogenesis | repressed |
| 6 | 36 | 35 | IL8, CCL2 | Inflammatory response, angiogenesis | repressed |
| 7 | 36 | 35 | EGF | Cell proliferation and differentiation | activated |
| 8 | 36 | 35 | TRAIL | Apoptosis | repressed |
| 9 | 36 | 35 | PLCB1 | Cell cycle regulation | repressed |
| 10 | 36 | 35 | JAK/Stat | Cell proliferation, apoptosis and differentiation | repressed |
| 11 | 36 | 35 | TP73, NCAM1 | Growth suppression, cell adhesion | repressed |
| 12 | 24 | 29 | p16, E2F4 | Negative regulation of cell cycle | repressed, activated |