Figure 7. Persistent low-grade chronic P. chabaudi infection does not affect MSP1₁₉-specific memory B cell responses.

(A) Cartoon showing the course of the experiment. Infected mice were treated either with 25 mg/Kg body weight of chloroquine (CQ) from day 30 of infection as described in Figure 2, or with normal saline (controls), and the number of MSP1₁₉ IgG ASC present after a second infection were compared between the two groups. (B) (i) Comparison of numbers of MSP1₁₉-specific IgG ASC in the spleens of CQ-treated (red circles) and untreated mice (blue circles). (ii) Comparison of numbers of MSP1₁₉-specific IgG ASC in the bone marrow of treated (red circles) and untreated (blue circles). (iii) Comparison of numbers of MSP1₁₉-specific IgG MBC in the spleens of treated (red dots) and untreated (blue dots). In each case, medians of 5 to 8 individual mice are shown. The numbers of ASC in the two groups at each time point were compared using a Mann Whitney test; * indicates the differences were significant (p values are shown), and ns no significant differences.