Table 3.
Mutations Patterns and Prevalence in pfmdr1 Gene in Isolates of P. falciparum Obtained from Children with Uncomplicated Malaria at Enrollment and after Treatment with CQ
| PFMDR1CODONS | |||||||
|---|---|---|---|---|---|---|---|
| Haplotypes | 86 | 184 | 1034 | 1042 | Pre-Treatment (%) [n=70] |
Post-Treatment (%) [n=26] |
P Values (χ2) |
| I | Tyr (Y) | Phe (F) | Ser (S) | Asn (N) | 5 (7%) | 8 (31%) | 0.007* (7.13) |
| II | Asn | Tyr | Ser | Asn | 12 (17%) | 1 (4%) | 0.17 |
| III | Asn | Phe | Ser | Asn | 8 (12%) | 5 (19%) | 0.5 |
| IV | Tyr | Tyr | Ser | Asn | 45 (64%) | 12 (46%) | 0.1 |
Mutant allele in boldface; Tyr (Y)= Tyrosine; Asn (N)= Asparagine; Phe (F)= Phenylalanine; Ser (S)= Serine
*
P value statistically significant.