Table 5.

Association between pfcrt/pfmdr1 Mutations in P. falciparum Isolates Obtained from Children at Enrollment and CQ In-Vitro Susceptibility Profile

In-Vitro Susceptibility Profile
Alleles of Genes/Haplotypes	Sensitive	Resistant	OR (95% CI)	P Value
*Pfcrt*
K76	15	8	3.553 (1.278–9.875)	0.013^*
T76	19	36	3.553 (1.278–9.875)	0.013^*
*Pfmdr1*
N86	16	10	2.590 (0.993–6.76)	0.05
Y86	21	34	2.590 (0.993–6.76)	0.05
Y184	23	34	0.203 (0.050–0.818)	0.029^*
F184	10	3	0.203 (0.050–0.818)	0.029^*
Pfmdr1Y86-Y184-S1034-N1042 haplotype
Present	15	31	4.133 (1.555–10.99)	0.004^*
Absent	20	10	4.133 (1.555–10.99)	0.004^*
*Mutants pfcrtT76 + pfmdr1* Y86**
Present	14	28	2.706 (1.103–6.635)	0.028^*
Absent	23	17	2.706 (1.103–6.635)	0.028^*
PfcrtT76+pfmdr1Y86-Y184-S1034-N1042 haplotype
Present	14	27	2.464 (1.009–6.002)	0.046^*
Absent	23	18	2.464 (1.009–6.002)	0.046^*
PfcrtK76+ Any pfmdr1 haplotype
Present	15	7	0.27 (0.096–0.764)	0.011^*
Absent	22	38	0.27 (0.096–0.764)	0.011^*

P value statistically significant; Alleles of pfcrt and pfmdr1 genes are the same as described in Table 2.