Table 6.

Association between pfcrt/pfmdr1 Mutations in P. falciparum Isolates Collected from Children at Enrollment and CQ Treatment Outcome

Alleles of Genes/Haplotypes	In-Vitro CQ Outcome		OR (95%CI)	P Value
Alleles of Genes/Haplotypes	Cured	Failed	OR (95%CI)	P Value
*Pfcrt*
K76	16	7	1.77 (0.628–4.983)	0.277
T76	31	24	1.77 (0.628–4.983)	0.277
*Pfmdr1*
N86	20	6	2.778 (0.967–7.981)	0.053
Y86	30	25	2.778 (0.967–7.981)	0.053
Y184	33	24	0.41 (0.102–1.661)	0.344
F184	10	3	0.41 (0.102–1.661)	0.344
Pfmdr1 Y86-Y184-S1034-N1042
Present	25	21	3.36 (1.157–9.759)	0.022^*
Absent	24	6	3.36 (1.157–9.759)	0.022^*
pfcrtT76+pfmdr1 Y86
Present	22	20	2.121 (0.856–5.258	0.102
Absent	28	12	2.121 (0.856–5.258	0.102
PfcrtT76+pfmdr1 Y86-Y184-S1034-N1042
Present	20	21	2.864 (1.138–7.209)	0.024^*
Absent	30	12	2.864 (1.138–7.209)	0.024^*
Pfcrt K76+any pfmdr1 haplotype
Present	16	6	0.49 (0.169–1.427)	0.187
Absent	34	26	0.49 (0.169–1.427)	0.187

P value statistically significant.

Alleles of pfcrt and pfmdr1 genes are the same as described in Table 2.