Table 2.

Relationship between biomarker expression and sensitivity and resistance to therapy

Marker	Median		Comparison and Result (at/above vs. below median for each marker)
	Median Percent Positive Cells	Range
Ki67	60%	1−90%	Low Ki67 score (<60%) significantly associated with resistance to therapy (RCB score of 3); p=0.01
p-STAT3	0%	0−100%	No association
p-ERK	70%	0−100%	No association
p-21	3%	0−60%	No association
p-27	10%	0−80%	No association
	Median Score	Range
RHEB	4	0−9	No association
AKT	3	0−9	No association

Note: Marker studies available for 33 cases for all markers expect for RHEB, which was available for 32 cases