Fig. 6.

(A-D) Representative experiment determining [Ca²⁺]_c and [Ca²⁺]_m in the same cell. [Ca²⁺]_c transients were elicited at 1 Hz in the absence and presence of isoproterenol (Iso, 1–100 nmol/L; (A), (C)). The [Ca²⁺] transients in (B) and (D) were recorded at the indicated time points of the protocol (arrows in (A), (C)). (E) and (F) Cytosolic (E) and mitochondrial Ca²⁺-transients (F) in the absence and presence of Ru360 (10 nmol/L)