Figure 6.

Flavopiridol (500 μM) treatment inhibits pRb phosphorylation and the rise in E2F1 levels. (A) Representative sections of cortex ipsilateral to occlusion from animals treated with vehicle or flavopiridol. Sections were obtained 24 h after reperfusion. (The black bar indicates 50 μm.) (B and C) Phospho-pRb-positive (B) and E2F1-positive (C) cells were quantified as described in the legend of Fig. 1. Each point represents a mean ± SEM (n = 4). * indicates significance (P < 0.05 as determined by repeated-measures ANOVA, followed by post hoc Tukey's highly significant difference) as compared with vehicle-treated controls.