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. Author manuscript; available in PMC: 2009 Nov 30.
Published in final edited form as: Ann Neurol. 2009 Sep;66(3):323–331. doi: 10.1002/ana.21738

Figure 7.

Figure 7

Hypoxia-ischemia and sepiapterin effects in neurobehavioral scoring for kits at E32 (P1). A. Dam sepiapterin treatment was initiated at E15 and finished at E22. Control dams were treated with vehicle only. At E22 dams were submitted to sustained H-I (40 min). Animals were allowed to recover as denoted by the period in broken line and to spontaneously deliver ~31.5 days term gestation. B. Number of newborn rabbit kits stillbirth and survivors having distinctive phenotypical motor performance (normal, mild, severe) after acute HI at E22. Motor function was assessed in the newborns (P1) in a blind manner and the scoring was according to Ashworth scale. Sepiapterin improved neurobehavioral outcome against any adverse outcome including death (p<0.005, Fisher exact test) and against severe motor deficits in survivors (p<0.001). Results represent analysis from 5 different litters.