Table 3.

Changes in dopamine, serotonin and metabolites in the brain after H-I injury with and without sepiapterin supplementation.

Dopamine (ng/mg protein)
	Control-Vehicle	Hypoxia	Sepiapterin
Thalamus	0.13±0.08	0.06±0.05#	0.17±0.03¶
Basal Ganglia	3.18±0.95	0.37±0.08#	1.19±0.42#,¶
Serotonin (ng/mg protein)
	Control-Vehicle	Hypoxia	Sepiapterin
Thalamus	3.20±0.90	2.20±0.37#	3.10±0.26¶
Basal Ganglia	3.38±0.56	3.71±0.73	3.52±0.89
HVA/5HIAAa
	Control-Vehicle	Hypoxia	Sepiapterin
Thalamus	1.19±0.18	0.86±0.07#	0.98±0.07¶
Basal Ganglia	1.15±0.13	0.52±0.14#	0.82±0.12¶

Values are Mean±S.E.M. (n=3-5).

^#p<0.05 from controls

^¶p<0.05 from hypoxia group.

^aHVA/5HIAA reference values for 0.5 years old 1.3-3.1²⁸.