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. Author manuscript; available in PMC: 2009 Nov 30.
Published in final edited form as: Acc Chem Res. 2008 May 24;41(7):793–804. doi: 10.1021/ar700246x

Figure 9.

Figure 9

Modeling the 8R and 8S epimers of the 5′-CpG-3′ acrolein-induced cross-links. A C•G pair is 5′ and a T•A pair is 3′ to the 5′-CpG-3′ sequence. A. 8R-diastereomer of carbinolamine cross-link 17, minor groove view. B. 8R-diastereomer of cross-link 17, base-stacking. C. 8S-diastereomer of cross-link 17, minor groove view. D. 8S-diastereomer of cross-link 17, base-stacking. E. 8R-diastereomer of pyrimidopurinone cross-link 19, minor groove view. F. 8R-diastereomer of cross-link 19, base-stacking. G. 8S-diastereomer of cross-link 19, minor groove view. H. 8S-diastereomer of cross-link 19, base-stacking. Copyright American Chemical Society 2005.