Table 5.
Library data for compounds 19{1–12}.
| compound | isocoumarin | amine | yielda (%) | purityc (%) |
|---|---|---|---|---|
| 19{1} | 11{64} | 20{1} | 46b | >99 |
| 19{2} | 11{64} | 20{2} | 50b | >99 |
| 19{3} | 11{64} | 20{5} | 57 | >99 |
| 19{4} | 11{64} | 20{6} | 54 | >99 |
| 19{5} | 11{64} | 20{7} | 70 | 95 |
| 19{6} | 11{64} | 20{8} | 29 | 97 |
| 19{7} | 11{65} | 20{1} | 63 | >99 |
| 19{8} | 11{65} | 20{2} | 64 | 96 |
| 19{9} | 11{66} | 20{1} | 16 | 92 |
| 19{10} | 11{66} | 20{3} | 24 | 96 |
| 19{11} | 11{67} | 20{3} | 25 | >99 |
| 19{12} | 11{67} | 20{4} | 26 | 90 |
a
Isolated yield after preparative HPLC.
b
Isolated yield after column chromatography.
c
UV purity determined at 214 nm after preparative HPLC.