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. Author manuscript; available in PMC: 2009 Dec 1.
Published in final edited form as: Ann N Y Acad Sci. 2008 Dec;1148:1–28. doi: 10.1196/annals.1410.082

Table 2.

Cell Signaling Related Genes

Probe Set ID UniGene ID UniGene Name 1×IMO Fold C (Up) Probe Set ID UniGene ID UniGene Name 6×IMO Fold C (Up)
Kinase/Phosphatase related genes Kinase/Phosphatase related genes

1368869_at Rn.122094 A kinase (PRKA) anchor protein 12 4.07 1367942_at Rn.3494 acid phosphatase 5 2.02
1368868_at 3.07 1398251_a_at Rn.9743 cal/cal-dependent pk II beta 3.23
1388686_at Rn.12942 Down syndrome critical region homolog 1 4.44 1372299_at Rn.92509 cyclin-dependent k inhibitor 1C 4.01
1368124_at Rn.10877 dual specificity phosphatase 5 7.01 1371446_at Rn.6276 MAPK-activated protein kinase 2 4.48
1371446_at Rn.6276 MAPK-activated protein kinase 2 4.28 1368902_at Rn.10128 p21-activated kinase 3 5.24
1368106_at Rn.12100 polo-like kinase 2 3.72 1382307_at Rn.58447 protein phosphatase 1(12A) 2.3
1384262_at Rn.30046 protein phosphatase 1(3B) 5.09 1384262_at Rn.30046 protein phosphatase 1(3B) 5.05
1386971_at Rn.37758 protein phosphatase 1(10) 3.86 1380045_at Rn.30021 PDP isoenzyme 2 4.19
1398807_at Rn.4143 protein phosphatase 1B, β 2.73 1370509_at 4.05
1371136_at 2.21 1371943_at Rn.4052 Ser/Thr-like protein kinase lyk4 3.56
1380045_at Rn.30021 PDP isoenzyme 2 4.12
1370509_at 3.82
1367936_at Rn.4190 serine/threonine kinase 10 3.08
1367802_at Rn.4636 serum/glucocorticoid regulated kinase 2.03
1368597_at Rn.42905 SNF1-like kinase 8
1368596_at 6.72
1368254_a_at Rn.18522 sphingosine kinase 1 2.74

(Down) (Down)
1369069_at Rn.91372 A kinase (PRKA) anchor protein 1 2.66 1369069_at Rn.91372 A kinase (PRKA) anchor protein 1 4.24
1370923_at Rn.36170 expressed in non-metastatic cells 6 2.52
1370100_at Rn.22497 PI-3-kinase, class 2 2.08
1369655_at Rn.30010 PI-3-kinase, class 3 2.61

G-protein related genes (Up) G-protein related genes (6×IMO) (Up)

1370649_at Rn.9845 bradykinin receptor b2 6.59 1370649_at Rn.9845 bradykinin receptor b2 14.24
1370650_s_at 3.89 1370650_s_at 4.97
1387596_at Rn.10543 thrombin receptor-like 1 2.36 1369624_at Rn.91303 prolactin releasing hormone 7.21
1387908_at Rn.54720 DEXRAS1 (Dexras1) 4.33
1384979_at Rn.92385 G protein-coupled receptor 50 2.53
1368029_at Rn.4368 guanine nucleotide binding protein 2.07

(Down) (Down)
1371635_at Rn.3566 transmembrane domain protein regulated 2.27 1370449_at Rn.87082G protein-coupled receptor 105 2.42

Calcium related genes (Up) Calcium related genes (6×IMO) (Up)

1387276_at Rn.80575 ania-4 4.78 1387276_at Rn.80575 ania-4 6.08
1370050_at Rn.7208 ATPase 2.56 1369117_at Rn.90085 cal/cal-related polypeptide, a 2.87
1369116_a_at Rn.90085 cal/cal-related polypeptide, a 15.17 1370000_at Rn.41602 nucleobindin 2
1369117_at 5.61
1370775_a_at 3.39
1369886_a_at Rn.23560 calcium binding protein 1 2.1

Channel related genes (1×IMO) (Up) Channel related genes (6×IMO) (Up)

1387477_at Rn.64577 potassium channel K12 3.01
1368751_at Rn.10878 potassium voltage-gated S3 3.44

(Down) (Down)
1368343_at Rn.10970 potassium voltage-gated channel, H2 2.18 1370757_at Rn.81221 calcium channel, 3 2.3
1369674_at Rn.10257 purinergic receptor P2X, 5 3.51 1369059_at Rn.86991 ChaK 3.29

Other Signaling related genes (Up) Other Signaling related genes (Up)

1368605_at Rn.30041 adaptor protein 2.38
1369468_at Rn.48736 frizzled homolog 4 (Drosophila) 2.97
1370454_at Rn.37500 homer homolog 1 (Drosophila) 11.33
1370997_at 8.78
1370669_a_at Rn.44869 phosphodiesterase 10A 10.63
1368438_at 8.96
1369044_a_at Rn.37733 phosphodiesterase 4B 2

(Down) (Down)
1368660_at Rn.42899 cAMP-GEFI 2.23 1398299_at Rn.105776 Rho GEF 11 2.14
1387499_a_at Rn.51153 phosducin-like 2.61 1393955_at Rn.79380 WD-containing protein 2.19
1370196_at Rn.14548 protein inhibitor of activated STAT 3 2.94 1371027_at Rn.21799 Cas-Br-M ectropic RTS b 3.02
1387186_at Rn.35289 RAB9, member RAS oncogene family 2.48
1369024_at Rn.3228 rabaptin 3.21

Bold – Genes changed by both types of stress; Fold C – Fold change