Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
JAK2/STAT1 and p38 signal pathways regulate SPE B-induced apoptosis in A549 cells. SPE B binds to integrin αVβ3 and Fas. Signals from both receptors activate the JAK2 and p38 pathways to phosphorylate tyrosine 701 and serine 727 of STAT1, respectively. Activated STAT1 translocates to the nucleus to activate the transcription of procaspase 8. Phospho-Ser-727 STAT1 is also a co-transactivator for the transcription of Bax.
