FIGURE 3.

JNK and Erks were required in B[a]PDE-induced cyclin D1 expression, but p38 was not. A, Beas-2B cells with or without chemical inhibitor pretreatment were exposed to B[a]PDE for 30 min and then subjected to Western blot analysis. B, Beas-2B cells pretreated with chemical inhibitors or not were exposed to B[a]PDE for 24 h and then subjected to Western blot analysis. C and D, Beas-2B DN-JNK mass1 cells and Beas-2B DN-Erk mass1 cells were exposed to 0.5 μm of B[a]PDE for 24 h and then subjected to Western blot analysis.