FIGURE 2.

α-Toc depletion does not increase APP expression nor β/γ-cleavages. A, the human APPsw mRNA expression did not increase in the brains of Ttpa^−/−APPsw mice compared with APPsw mice. The band intensities normalized to the mouse glyceraldehyde-3-phosphate dehydrogenase (GAPDH) bands are shown in the right panel. B, protein levels of C-terminal fragments of APP-β, -α, and -γ/ϵ did not change in the brains of Ttpa^−/−APPsw mice compared with APPsw mice. Band intensities are shown in the right panel. C and D, the β (C)- and γ (D)-secretase activities did not increase in the brains of Ttpa^−/− mice compared with wild-type mice.