FIG. 8.

Effect of modafinil administered during the light phase on hippocampal cell survival in the rat. Cell survival was measured in the dentate gyrus (DG) and this total is subdivided into counts in the subgranular zone/ granule cell layer (SGZ/GCL) and hilus. Modafinil (300 mg/kg) or drug vehicle were administered every 4 hours (3 injections total), starting at the onset of the 12-h light phase. Animals were sacrificed 21 days after BrdU injection. Values are means ± SEM; n = 6 for vehicle; n = 5 for modafinil. * P < 0.01 vs. vehicle; by unpaired (two-tailed) t test.