Fig. 5.

Adipose- specific atg7 conditional knockout mice exhibited increased insulin sensitivity. (A) Glucose tolerance tests. Control mice (male, n = 6) and atg7 conditional knockout mice (male, n = 6) were fasted overnight before receiving an i.p. injection of 2 g/kg glucose and blood glucose concentration was measured at indicated time points. (B) Insulin tolerance tests. Control mice (male, n = 6) and atg7 conditional knockout (male, n = 6) mice were fasted for 5 h before receiving an i.p. injection of 0.75 U/kg insulin and blood glucose concentration were measured at indicated time points. (C) Plasma insulin levels of the control (male, n = 6) and atg7 conditional knockout mice (male, n = 6) fasted for 5 h. *, P < 0.05; **, P < 0.01, Student's t test. These data are representative results from two independent experiments.