Fig. 1.

Effects of the CRF₁ receptor antagonist R121919 (−1 h pretreatment, 0, 5, 10, and 20 mg/kg, s.c.) on cumulative 3-h food intake in (A) P phase (upon renewed access to the palatable food), (B) C phase (when rats had been withdrawn from the palatable diet to chow), and (C) amplitude of cycling (the difference between P phase and C phase intakes after a history of alternating Chow/Palatable diet access in male Wistar rats; n = 20) (see Materials and Methods or Fig. S1 for diet schedule). R121919 increased chow intake and decreased palatable diet intake in Chow/Palatable rats with no effect in Chow/Chow rats. Rats were tested after seven cycles of diet alternation. Doses were given in a within-subjects design before the first chow day or before the first palatable day of four consecutive cycles, respectively. Panels show M± SEM. $$, P < 0.01, $$$, P < 0.001, linear contrast dose effect; #, P < 0.05, ##, P < 0.01, ###, P < 0.001, main dose effect; *, P < 0.05, **, P < 0.01, ***, P < 0.001, different from vehicle.