TABLE 1.

RB69-HCMV DNA polymerase chimera

Nomenclature for chimera (block)	Region	RB69 residues	HCMV residues	Comments
A	Helix N	Val-478	Trp-780	None
		Phe-479	Val-781
		Asn-480	Ser-782
A/V781I	Helix	Chimera A V479I	Chimera A V781I	Foscarnet resistance conferring mutationa
B	Helix P	Ile-557	Met-808	None
		Asn-558	Ala-809
		Arg-559	Leu-810
C	Helix P	Leu-601	Val-812	None
		Leu-602	Thr-813
		Ile-603	Cys-814
ABC/R784A	Helix N	Chimera A	Chimera A
		R482A	R784A	Conserved residue
	Helix P	Chimera BC	Chimera BC
ABC/Q807A	Helix N	Chimera A	Chimera A
	Helix P	Chimera BC	Chimera BC
		Q556A	Q807A	Conserved residue conferring resistance to foscarnetb

^a A 5.2-fold increase in foscarnet resistance is indicated (62).

^b A 6-fold increase in foscarnet resistance is shown (42).