TABLE 1.
Phosphorylated proteins in galectin-1-stimulated MDDCs relative to buffer control using corrected fold change from Kinex array
| Protein name | Phosphorylation site(s) | Corrected fold change | Known signaling pathwaysa |
|---|---|---|---|
| Caveolin 2 | Ser23 | 14.73 | Scaffolding protein |
| Myosin regulatory light chain | Ser20 | 2.79 | Integrin signaling, Rho-dependent signaling |
| ζ-chain (TCR)b-associated kinase, 70 kDa (ZAP-70/spleen tyrosine kinase (Syk) | Tyr292 | 1.78 | MAPK signaling, TCR signaling |
| Protein kinase N1 (PKN1) | Thr774 | 1.62 | Inositol phosphate signaling, PKC signaling, Rho-dependent signaling |
| Phosphatase and tensin homolog (PTEN), pseudogene 1 (PTENP1) | Ser380, Ser382,and Ser385 | 1.55 | Inositol phosphate signaling, integrin signaling |
| Insulin receptor substrate 1 (IRS-1) | Tyr612 | 1.49 | Insulin receptor signaling, inositol phosphate signaling |
| LIM domain kinase 1/2 | Try508/Thr505 | 1.43 | Rho-dependent signaling, inositol phosphate signaling |
| Myristoylated alanine-rich protein kinase C substrate (Marcks) | Ser158 and Ser162 | 1.42 | PKC signaling |
| MAPK-interacting protein-serine kinase 1 (MNK1) | Thr209 and Thr214 | 1.38 | MAPK signaling |
| Retinoblastoma-associated protein 1 | Ser807 | 1.37 | Cell cycle |
| cAMP-responsive element binding protein 1 (CREB) | Ser133 | 1.32 | cAMP signaling, MAPK signaling, Calcium signaling |
| Ret receptor-tyrosine kinase | Ser696 | 1.31 | MAPK signaling, inositol phosphate signaling |
a Known signaling pathways obtained from ingenuity pathway analysis and EntrezGene data bases.
b TCR, T-cell receptor.