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. Author manuscript; available in PMC: 2010 Jul 1.

Published in final edited form as: J Am Chem Soc. 2009 Jul 1;131(25):9038–9045. doi: 10.1021/ja902677t

Scheme 6 — Functionalization of Alkyne 27.a

^aReagents and Conditions: a) A1Me₃, Cp₂ZrCl₂, CH₂Cl₂, 0 °C, 62%; b) TBSOTf, 2,6-lutidine, CH₂Cl₂, 0 °C, 94%; c) Me₃SiSnBu₃, Pd(PPh₃)₄, THF, reflux, 85%; d) I₂,2,6-di-t-butyl-4-methylpridine, CH₂Cl₂, −40 °C, 93%; e) MeLi, CuI, THF, −20 °C, 98%; f ) NIS, CH₃CN, rt,82%.