Skip to main content
. Author manuscript; available in PMC: 2009 Nov 30.
Published in final edited form as: J Immunol. 2009 Jun 26;183(2):1144–1154. doi: 10.4049/jimmunol.0900788

Figure 2. CpG ODN-induced fetal resorption in IL-10−/− occurs with rapid kinetics and is TLR-9 dependent.

Figure 2

(A) Representative uterine horns of control and CpG ODN-treated IL-10−/− mice harvested on gd7, gd8 and gd9 represent multiple experiments on kinetic evaluation on the insult of placental pathologies. (B) Representative uterine horns harvested on gd9 from IL-10−/− mice treated on gd6 with antagonist ODN 2088 (50 µg) (top panel), antagonist ODN (50 µg) plus stimulatory CpG ODN (25 µg) (middle panel), and CpG ODN alone (bottom panel) are shown. Data demonstrate antagonistic binding of antagonist ODN to TLR-9 prevented fetal resorption (n=4 animals per treatment).