Table I.
Rescue of CpG ODN-induced preterm birth in IL-10−/− mice
| Strain | Treatment | n | gd birtha | p-value |
|---|---|---|---|---|
| C57BL/6 IL-10−/− | CpG ODN + Isotype Abb | 3 | 15.5±0.5 | |
| Control ODN + anti-TNF-α | 3 | 20.0±1.0 | ||
| CpG ODN + anti-TNF-α | 4 | 20.6±0.8 | <0.001c | |
| CpG ODN + Isotype Abd | 3 | 15.2±0.3 | ||
| Control ODN + anti-F4/80 | 3 | 19.7±1.1 | ||
| CpG ODN + anti-F4/80 | 4 | 20.1±0.8 | <0.001 |
a
Gestational day of birth was assessed visually by the presence of live or dead pups delivered post gd14 treatment
b
Isotype antibody paired to anti-TNF-α administration is listed in Materials and Methods
c
P-value compares significance of gd of birth between CpG ODN + antibody to CpG ODN + Isotype Ab
d
Isotype antibody paired to anti-F4/80 administration is listed in Materials and Methods