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. 2009 Sep 16;1(4):e00016. doi: 10.1042/AN20090036

Figure 8. Working model of NeuroD6-mediated co-ordination of mitochondrial mass with cytoskeletal rearrangement in PC12-ND6 cells.

Figure 8

NeuroD6 induces cytoskeletal remodelling, appropriate stage-specific redistribution of MAP-1A and MAP-2, as well as a gradient of unphosphorylated tau in developing processes of stage III PC12-ND6 cells, which facilitate efficient binding of KIF5B with mitochondria in the proximal portion of the developing axon and the release of KIF5B with its cargo at the distal portion of the developing axon.