Table 1. Demographics of patients used in the present study.
Demographic | Unmedicated patients with unipolar depression (n = 31) | Healthy comparison subjects (n = 31) | Between-group differences |
Age (years) | 39.2±11.9 | 36.7±10.7 | F (1,60) = 0.73P = 0.40 |
Female (n) | 77% (24) | 77% (24) | X2 = 0P = 1.0 |
Right-handed (n) | 100% (31) | 94% (29) | X2 = 2.07P = 0.49 |
Education level (years) | 15.4±3.4 | 15.3±2.7 | F (1,60) = 0.55P = 0.40 |
Race | |||
Caucasian (n) | 100% (31) | 93% (29) | X2 = 1.0P = 0.60 |
African-American (n) | 0 | 7% (2) | – |
Other (n) | 3% (1) | 0 | – |
HDRS | 11.8±9.1 | – | – |
Duration of illness (years) | 11.42±10.6 | – | – |
Age at onset (years) | 27.9±11.6 | – | – |
Number of episodes | 5.1±5.9 | – | – |
Current mood state | – | – | |
Depressed (n) | 65% (20) | – | – |
Euthymic (n) | 35% (11) | – | – |
Family history positive (n) | 65% (20) | – | – |
Medication naïve (n) | 58% (18) | – | – |
Previous atypical antipsychotic use (n) | 16% (5) | – | – |
Previous antidepressant use (n) | 42% (13) | – | – |
Hippocampal volume (mm3) | – | – | |
Right | 1911.1±280.1 | 1828.9±284.2 | F (1,59) = 2.03P = 0.16 |
Left | 1885.4±230.8 | 1851.9±326.8 | F (1,59) = 2.26P = 0.14 |