Resolvin D1 (RvD1) counters GS-HNE-stimulated peritonitis. Mice were injected i.v. with RvD1 (0.01–10.0 ng; A) immediately before administration of GS-HNE (10 µg intraperitoneally). After 4 h, the peritoneal cavity was lavaged and PMN numbers were determined (see Methods). Sections from the peritoneal lining (haematoxylin and eosin stained) obtained for histological analysis are shown in (B) (top; original magnification 10×) with increased magnification in the lower panels. Results are presented as mean ± SEM (n= 3–5), *P < 0.05, **P < 0.01. GS-HNE, glutathionyl-4-hydroxy-trans-2-nonenal; PMN, polymorphonuclear leukocyte.